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产品介绍
Overview
属性
熔点 | 283-285°C |
溶解性 | Soluble in ethanol (5 mg/ml warm), DMSO (>25 mg/ml warm), and DMF. Insoluble in water. |
存贮条件 | 存储温度2-8℃ |
密度 | 1.0900 |
描述
应用 | An anti-angiogenic and anti-proliferative agent |
产品介绍 | 存在于天然植物中的一种三萜类化合物。不溶于水,溶于2%酒精的NaOH,溶于热冰醋酸,中度溶于丙酮,微溶于醇、醚、氯仿和二硫化碳。 |
生化机理 | Ursolic Acid, a naturally occurring triterpenoid, has been noted to demonstrate anti-angiogenic and anti-proliferative properties. Mechanistic studies suggest that this compound down-regulates MMP-2 and uPA expression in cells via inhibition of Akt, JNK, mammalian target of Rapamycin phosphorylation, and levels of NFκB protein in the nucleus. Other experiments have shown that Ursolic Acid may improve blood glucose, glucose tolerance, insulin tolerance, glycosylated hemoglobin, and plasma leptin levels in diabetic murine models. Additionally, this agent displays a capacity to induce cell cycle arrest and apoptosis through activation of p53 pathway and Bax protein, as well as down-regulation of Bcl-2. |
别名 | 乌苏酸;乌索酸;3-羟基-(3β)-乌索-12-烯-28-酸;3β-Hydroxy-12-ursen-28-ic acid |
Reaxys-RN | 2228563 |
Merck Index | 9890 |
个人防护设备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
WGK德国 | NWG |
安全声明(欧洲) | S24/25; |
技术参数
Specifications
如需产品COA 或者 MSDS,请登录 阿拉丁网站:http://www.aladdin-e.com/zh_cn/customsearch/result/coa/#coa-fancybox
产品应用
Applications
规格参数 | |
品牌 | 阿拉丁Aladdin |
类别 | 天然产物 研究领域 |
CASNo. | 77-52-1 |
纯度 | 93% |
包装规格 | 250mg |
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